Publications

25- M, Wojciech, K. M. Stringer, T. Enzlein, Melissa K Passarelli, S. Escrig, K. Vitanova, J. Wood, K. Blennow, H. Zetterberg, A. Meibom, C. Hopf, F. A. Edwards, J. Hanrieder. Following spatial AB aggregations dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics. Science Advances. 7, 25 (2021).

24- A. Race, A. Rae, JL Vorng, R. Havelund, A. Dexter, N. Kumar, R. Steven, Melissa K. Passarelli, B.Tyler, J. Bunch and I. Gilmore ”Correlative hyper-spectral imaging using a dimensionality reduction based image fusion method” Analytical Chemistry 92 (16), 10979-10988 (2020).

23- J. Decelle, G.Veronesi, B. Gallet, H. Stryhanyuk, P. Benettoni, M. Schmidt, R.Tucoulou, Melissa K. Passarelli, S. Bohic, P. Clode, and N. Musat. Subcellular Chemical Imaging: New Avenuesin Cell Biology. Trends in Cell Biology 30 (3), 173-188 (2020).

22- A. Satoka, K. Yuuki, Melissa K. Passarelli, J.L. Vorng, T. Kawashima, K. Yoshikiyo, T.Yamamoto andI. Gilmore. OrbiSIMS imaging identifies molecular constituents of the perialgal vacuole membrane of Paramecium bursaria with symbiotic Chlorella variabilis. Analytical Chemistry 91 (22), 14545-14551 (2019).

21- Melissa K. Passarelli, A. Pirkl, R. Moellers, D. Grinfeld, F. Kollmer, R.Havelund, C. Newman, P.Marshall, H. Arlinghaus, M. Alexander, A. West, S. Horning, E. Niehuis, A. Makarov, C. Dollery and I.Gilmore. The 3D OrbiSIMS: A New Method for Label-Free Metabolic Imaging with Sub-cellular Lateral Resolution and High Mass Resolving Power. Nature Methods 14, 1175-1183 (2017).

20- C. Newman, R. Havelund, Melissa K. Passarelli, P. Marshall, I. Francis, A.West, M. Alexander, I.Gilmore and C.T. Dollery. Intracellular Drug Uptake: a Comparison of Single-cell and Cell Population Measurements using ToF-SIMS Imaging Combined with Quantitative LC-MS/MS. Analytical Chemistry89 (22), 11944-11953 (2017).

19- I.H. Barientos, E. Paladino, P. Szabo, S. Brozio, P. Hall, C. Oseghale, Charles, Melissa K. Passarelli, S.Moug, R. Black, C.Wilson, R. Zelko, D. Lamprou. Electrospun Collagen-Based Nanofibers: A Sustainable Material for Improved Antibiotic Utilisation in Tissue Engineering Applications. International Journal of Pharmaceutics 531 (1), 67-79 (2017).

18- C.A. Griths, R. Sagar, Y. Geng, L.F. Primavesi, M.K. Patel, Melissa K. Passarelli, I.S. Gilmore, R.T.Steven, J. Bunch, M.J. Paul, B.G. Davis. Chemical Intervention in Plant Sugar Signaling Increases Yield and Resilience. Nature 540 (7634), 574-578. (2016).

17- H.Jiang, Melissa K. Passarelli, P.M.G. Munro, M.R. Kilburn, A. West, C.T. Dollery, I.S. Gilmore, P.Rakowska. High-resolution Sub-cellular Imaging by Correlative NanoSIMS and Electron Microscopy of Amiodarone Internalisation by Lung Macrophages as the Evidence for Drug-induced Phospholipidosis. Chemical Communications 53 (9), 1506-1509 (2016).

16- I.J. Hall Barrientos, E.Paladino, S.Brozio, Melissa K. Passarelli, S. Moug, R.A. Black, C. G. Wilson,D. A. Lamprou. Fabrication and Characterisation of drug-loaded Electrospun Polymeric Nanofibers for Controlled Release in Hernia Repair. International Journal of Pharmaceutics 517 (1-2), 329-337 (2016).

15- J.L. Vorng, A. M. Kotowska, Melissa K. Passarelli and A. West, P. Marshall, R. Havelund, M. Seah,C.T. Dollery, P. Rakowska, I. Gilmore. Semi-Empirical Rules to Determine Drug Sensitivity and Ionization Efficiency in SIMS using a Model Tissue Sample. Analytical Chemistry 88 (22), 11028-11036 (2016).

14- Y. Yokoyama, S. Aoyagi, M. Fujii, J. Matsuo, J.S. Fletcher, N.P. Lockyer, J.C. Vickerman, Melissa K. Passarelli, R.Havelund, and M.P. Seah. Peptide Fragmentation and Surface Structural Analysis by Means of ToF-SIMS using Large Cluster Ion Sources. Analytical Chemistry 88 (7), 3592-3597(2016).

13- T. Sainsbury, Melissa K. Passarelli, M. Naftaly, S. Gnaniah, S. J. Spencer, and A.J. Pollard. Covalent Carbene-Functionalization of Graphene: Towards Chemical Band Gap Manipulation. ACS Applied Materials and Interfaces 8 (7), 4870-4877 (2016).

12- Melissa K. Passarelli, C. Newman, P. Marshall, A. West, I. S. Gilmore, J. Bunch, M. Alexander and C.T. Dollery. Single-cell Analysis: Visualizing Pharmaceutical Compounds in Cells with Label-free 3D Mass Spectrometry Imaging. Analytical Chemistry 87 (13), 6696-6702 (2015).

11- T. Sainsbury, A. ONeill, Melissa K. Passarelli, M. Seraon, D. Gohil S. Gnaniah S. J. Spencer, A. Rae,J. N. Coleman. Dibromocarbene Functionalization of Boron Nitride Nanosheets: Towards Band-Gap Manipulation and Nanocomposite Applications. Chemistry of Materials 26 (24), 7039-7050 (2014).

10- Melissa K. Passarelli, J. Wang, R. Trouillon, A.S. Mohammadi, I. Gilmore and A.G. Ewing. Development of an Organic Lateral Resolution Test Device for Imaging Mass Spectrometry. Analytical Chemistry85 (2), 522-542 (2014).

9- Melissa K. Passarelli and A.G. Ewing. Single-cell Imaging Mass Spectrometry. Current Opinion in Chemical Biology,17 (5), 854-859 (2013). *Cover

8- R. Trouillon, Melissa K. Passarelli, J. Wang, M.E. Kurczy and A.G. Ewing. Chemical Analysis of Single-cells. Analytical Chemistry 85 (2), 522-542 (2013). *Republished in JACS Select: The BRAIN initiative (Dec 2013).

7- Melissa K. Passarelli, A. Ewing and N. Winograd. Single Cell Lipidomics: Characterizing and Imaging Lipids on the Surface of Individual Aplysia Californica Neurons with Cluster SIMS. Analytical Chemistry 85 (4), 2231-2238 (2013). Republished in Virtual Issue: Lipidomics (August 2014).

6- Melissa K. Passarelli, A.G. Ewing and N. Winograd, C60-SIMS Studies of Glycerophospholipids in a LIPID MAPS Model system: KDO2-Lipid A Stimulated RAW 264.7 Cells. Surface Interface Analysis45 (1), 298-301 (2012).

5- Melissa K. Passarelli and N. Winograd. Lipid Imaging With Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). BBA Molecular and Cell Biology of Lipids 1811, 976-990 (2011).

4- Melissa K. Passarelli and N. Winograd. Characterizing In Situ Glycerophospholipids with SIMS and MALDI Methodologies. Surface Interface Analysis 43, 269-271 (2011).

3- A. Carado, Melissa K. Passarelli, J. Kozole, J. E. Wingate, N. Winograd and A. V. Loboda. C60+ SIMS with a Hybrid-Quadrupole Orthogonal Time-of-Flight Mass Spectrometer. Analytical Chemistry 80, 7921-7929 (2008).

2- A. Carado, J. Kozole, Melissa K. Passarelli, N. Winograd, A. Loboda and J. Wingate. Cluster SIMSwith a Hybrid Quadrupole Time-of-Flight Mass Spectrometer. Applied Surface Science 255, 1610-1613(2008).

1- A. Carado, J. Kozole, Melissa K. Passarelli, N. Winograd, A. Loboda, J. Bunch, J. Wingate, J. Hankin and R. Murphy. Biological Tissue Imaging with a Hybrid Cluster SIMS Quadrupole Time-of-Flight Mass Spectrometer. Applied Surface Science 255, 1572-1575 (2008).